- 原著論文
論文発表：The role of HIV-1 Gag and genomic RNA interactions in virion assembly.
野間口雅子先生、駒貴明先生らの論文「The role of HIV-1 Gag and genomic RNA interactions in virion assembly.」が掲載されました。
掲載誌等：Frontiers in Microbiology, 16, 1642090, 2025.
DOI：10.3389/fmicb.2025.1642090
著者：Takaaki Koma, Bao Quoc Le, Khanh Quoc Tran, Naoya Doi, Tomoyuki Kondo, Kei Miyakawa, Akio Adachi and Masako Nomaguchi
DOI：10.3389/fmicb.2025.1642090
著者：Takaaki Koma, Bao Quoc Le, Khanh Quoc Tran, Naoya Doi, Tomoyuki Kondo, Kei Miyakawa, Akio Adachi and Masako Nomaguchi
要約：The virion assembly represents a critical aspect of producing infectious progenies required for HIV-1 replication. Each step in that process, such as Gag-membrane binding, Gag-genomic RNA binding/packaging, Gag multimerization, and viral particle budding, has been extensively analyzed in a stepwise and specific manner. While Gag proteins are the primary drivers of HIV-1 virion assembly, the interactions between Gag and RNA play a significant role in regulating the process. This article provides an updated overview and perspective on HIV-1 virion assembly, with a particular focus on the role of Gag-RNA interactions.
