- 原著論文
論文発表：Pathological Insights into Lassa Virus-Induced Vestibular Dysfunction in Mice: Histopathological Analysis of the Inner Ear Vestibular Apparatus
駒貴明先生らの論文「Pathological Insights into Lassa Virus-Induced Vestibular Dysfunction in Mice: Histopathological Analysis of the Inner Ear Vestibular Apparatus」が掲載されました。
掲載誌等：The Journal of Infectious Diseases, 231, 4, 1074-1078, 2025.
DOI：10.1093/infdis/jiae516
著者：Tomoharu Suzuki, Marina Hosotani Saito, Nantian Lin, Atsushi Tamura, Nadezhda Yun, Takaaki Koma, Junki Maruyama, Slobodan Paessler and Tomoko Makishima
DOI：10.1093/infdis/jiae516
著者：Tomoharu Suzuki, Marina Hosotani Saito, Nantian Lin, Atsushi Tamura, Nadezhda Yun, Takaaki Koma, Junki Maruyama, Slobodan Paessler and Tomoko Makishima
要約：Lassa fever (LF), caused by Lassa virus (LASV) infection, typically leads to mild symptoms in humans, but some survivors experience audiovestibular problems. Here we present vestibular histopathological insights in our LF model mice. We observed (1) hemorrhage within the vestibular ganglion and stroma beneath the sensory epithelium, (2) preserved hair cells and supporting cells, (3) LASV antigen presence in the vestibular ganglion cells and the stroma beneath the sensory epithelium, and (4) CD3-positive T-lymphocyte infiltration in the vestibular ganglion and the stroma underlying the sensory epithelium. LASV and/or its immune response likely contributes to the pathogenesis of vestibular dysfunction.
キーワード：inner ear / Lassa fever / Lassa virus / pathology / vestibular apparatus
